Pain pathway in a dish could aid search for new analgesic drugs

Scientists have recreated a pathway that senses pain, using clusters of human nerve cells grown in a dish.

Apr 10, 2025 - 13:46

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Pain pathway in a dish could aid search for new analgesic drugs

Researchers integrated four organoids that represent the four components of the human sensory pathway, along which pain signals are conveyed to the brain. Stimulation of the sensory organoid (top) by substances, such as capsaicin, triggers neuronal activity that is then transmitted throughout the rest of the organoids.

Scientists have recreated a pathway that senses pain, using clusters of human nerve cells grown in a dish.

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