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Marsupial embryos lack the epigenetic reset seen in placental mammals
Nature, Published online: 14 May 2025; doi:10.1038/d41586-025-01477-2Biochemical ‘DNA methylation’ marks are found across the genome in vertebrate animals, but in the early embryos of placental mammals, such as mice and humans, they are largely erased in a ‘system reset’. Surveying DNA methylation in opossum embryos reveals that, in marsupials, such marks are retained.
Nature, Published online: 14 May 2025; doi:10.1038/d41586-025-01477-2Biochemical ‘DNA methylation’ marks are found across the genome in vertebrate animals, but in the early embryos of placental mammals, such as mice and humans, they are largely erased in a ‘system reset’. Surveying DNA methylation in opossum embryos reveals that, in marsupials, such marks are retained.
