Macrophages harness hepatocyte glutamate to boost liver regeneration
Nature, Published online: 26 March 2025; doi:10.1038/s41586-025-08778-6Glutamate metabolically reprograms bone-marrow-derived macrophages, stabilizing HIF1α, which transcriptionally activates WNT3 to promote YAP1-dependent hepatocyte proliferation, boosting liver regeneration.
Nature, Published online: 26 March 2025; doi:10.1038/s41586-025-08778-6Glutamate metabolically reprograms bone-marrow-derived macrophages, stabilizing HIF1α, which transcriptionally activates WNT3 to promote YAP1-dependent hepatocyte proliferation, boosting liver regeneration.
