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UM171 glues asymmetric CRL3–HDAC1/2 assembly to degrade CoREST corepressors

Nature, Published online: 12 February 2025; doi:10.1038/s41586-024-08532-4UM171 promotes corepressor degradation by acting as a molecular glue to induce KBTBD4–HDAC1/2 interactions with the help of inositol hexakisphosphate.

Feb 13, 2025 - 00:50
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UM171 glues asymmetric CRL3–HDAC1/2 assembly to degrade CoREST corepressors

Nature, Published online: 12 February 2025; doi:10.1038/s41586-024-08532-4UM171 promotes corepressor degradation by acting as a molecular glue to induce KBTBD4–HDAC1/2 interactions with the help of inositol hexakisphosphate.

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