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Structural dynamics of DNA unwinding by a replicative helicase
Nature, Published online: 19 March 2025; doi:10.1038/s41586-025-08766-wCryo-electron microscopy structures of DNA helicases in various conformations provide insight into an ATP-hydrolysis-dependent ‘entropy switch’ that drives unwinding of DNA for replication, with probable conservation across viral and eukaryotic systems.
Nature, Published online: 19 March 2025; doi:10.1038/s41586-025-08766-wCryo-electron microscopy structures of DNA helicases in various conformations provide insight into an ATP-hydrolysis-dependent ‘entropy switch’ that drives unwinding of DNA for replication, with probable conservation across viral and eukaryotic systems.
