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Re-adenylation by TENT5A enhances efficacy of SARS-CoV-2 mRNA vaccines
Nature, Published online: 16 April 2025; doi:10.1038/s41586-025-08842-1Upon intramuscular administration, COVID-19 mRNA vaccines are primarily taken up by macrophages, in which the cellular machinery extends their poly(A) tails, thereby increasing mRNA stability and translation, providing an explanation for the efficacy of these vaccines.
Nature, Published online: 16 April 2025; doi:10.1038/s41586-025-08842-1Upon intramuscular administration, COVID-19 mRNA vaccines are primarily taken up by macrophages, in which the cellular machinery extends their poly(A) tails, thereby increasing mRNA stability and translation, providing an explanation for the efficacy of these vaccines.
